Note: After you apply this mute feature, it will work on that entire website and not only on that web page being explored by you. For Mac user, you will have to click on the Tab menu from the Chrome menu bar and choose to mute site.This step can be used for both Windows and Mac: you will have to right-click on the window title bar of the site, which is playing sound, and click on Mute site.Now, go to the website you want to mute.How to Mute a Tab in Chrome on Mac and Windows PC How to Mute a Tab in Chrome on Mac and Windows PC.In the Chrome browser on Mac or Windows PC, you can easily mute a tab in two different ways. Thankfully, there is a way to perfectly deal with that unsolicited stuff. If you haven’t silenced the sound, you can experience an intense glare from people sitting around. The moment you open a web page on your computer, it will start playing audio or video.